New technology can pinpoint and fix the defective gene

Science and Technology Daily News According to physicist organizational networks reported on August 13, the use of human pluripotent stem cells and DNA from bacterial meningitis cutting protein, U.S. Moggridge Institute and Northwestern University researchers have developed a can Published in the August 12 issue of the American "National Academy of Sciences," the paper said the new technology is much simpler than previous methods, regenerative medicine, drug screening and basic biomedical research areas a significant progress.

HOU Steel, said: "With this system, we can fix almost any genetic defects, including those that may cause cancer genetic defects. Moreover, the technology can also be used for human pluripotent stem cells, which have the imagination for other applications opens the door Northwestern University, where Zhang Yang's research team focused on the Neisseria meningitidis bacteria, because they are the best source of protein Cas9 while using Cas9 protein, you can accurately cut the damaged DNA fragments.

He said: "We can use different types of small RNA molecules to guide this protein, which allows us to precisely remove, replace or correct the defective gene, while the previous methods are mostly built on the basis of technical protein Embryonic Stem Cell Biology, University of Wisconsin Professor James Thomson, other than professors and scholars believe that the study has many practical applications. Professor Thomson said: "The human pluripotent stem cells can be unlimited proliferation, they produce vital for all human cell types, so for regenerative medicine, drug discovery and biomedical research, they are extremely valuable.

Through the Northwestern University Department of Molecular Biology at Northwestern University professor Eric Song Timo Er said the study results also showed that while the technology security. He said: "Prior to the study, incidental or off-target cuts are scientists had to face a problem, these problems make regenerative medicine applications facing some potential adverse effects of new technologies not only overcome these safety barriers , also known for its convenience features make relevant research from a complex project into a conventional experimental techniques, this research in terms of the technology after the far-reaching significance. "